CD56^dim CD57^- NKG2C⁺ NK cells retaining proliferative potential are possible precursors of CD57⁺ NKG2C⁺ memory-like NK cells.

ABSTRACT: Formation of the adaptive-like NK cell subset in response to HCMV infection is associated with epigenetic rearrangements, accompanied by multiple changes in the protein expression. This includes a decrease in the expression level of the adapter chain FcεRIγ, NKp30, and NKG2A receptors and an increase in the expression of NKG2C receptor, some KIR family receptors, and co-stimulating molecule CD2. Besides, adaptive-like NK cells are characterized by surface expression of CD57, a marker of highly differentiated cells. Here, it is shown that CD57-negative CD56^dim NKG2C⁺ NK cells may undergo the same changes, as established by the similarity of the phenotypic expression pattern with that of the adaptive-like CD57⁺ NKG2C⁺ NK cells. Regardless of their

SUBMITTER: Kobyzeva PA 

PROVIDER: S-EPMC8932339 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature