Avalanches during epithelial tissue growth; Uniform Growth and a drosophila eye disc model.

ABSTRACT: Epithelial tissues constitute an exotic type of active matter with non-linear properties reminiscent of amorphous materials. In the context of a proliferating epithelium, modeled by the quasistatic vertex model, we identify novel discrete tissue scale rearrangements, i.e. cellular rearrangement avalanches, which are a form of collective cell movement. During the avalanches, the vast majority of cells retain their neighbors, and the resulting cellular trajectories are radial in the periphery, a vortex in the core. After the onset of these avalanches, the epithelial area grows discontinuously. The avalanches are found to be stochastic, and their strength is correlated with the density of cells in the tissue. Overall, avalanches redistribute accumulated local spatial pressure along the tissue

SUBMITTER: Courcoubetis G 

PROVIDER: S-EPMC8932575 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature