Extrathoracic multiple trauma dysregulates neutrophil function and exacerbates pneumonia-induced lung injury.

ABSTRACT:

Background

Forty percent of critically ill trauma patients will develop an infectious complication. Pneumonia is the most common cause of death of trauma patients surviving their initial insult. We previously demonstrated that polytrauma (PT), defined as two or more severe injuries in at least two areas of the body, induces emergency hematopoiesis characterized by accelerated myelopoiesis in the bone marrow and increased myeloid cell frequency in the peripheral tissues. We hypothesized that PT alone induces priming of neutrophils, resulting in hyperactivation upon secondary exposure to bacteria and causing acute lung injury and increased susceptibility to secondary exposure to Pseudomonas aeruginosa pneumonia.

Methods

C57BL/6 mice were subjected to PT consisting of a lower e

SUBMITTER: Leonard JM 

PROVIDER: S-EPMC8932930 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature