Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children's blood.
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ABSTRACT:
SUBMITTER: Ruiz-Arenas C
PROVIDER: S-EPMC8933004 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children's blood.
Ruiz-Arenas Carlos C Hernandez-Ferrer Carles C Vives-Usano Marta M Marí Sergi S Quintela Ines I Mason Dan D Cadiou Solène S Casas Maribel M Andrusaityte Sandra S Gutzkow Kristine Bjerve KB Vafeiadi Marina M Wright John J Lepeule Johanna J Grazuleviciene Regina R Chatzi Leda L Carracedo Ángel Á Estivill Xavier X Marti Eulàlia E Escaramís Geòrgia G Vrijheid Martine M González Juan R JR Bustamante Mariona M
eLife 20220318
<h4>Background</h4>The identification of expression quantitative trait methylation (eQTMs), defined as associations between DNA methylation levels and gene expression, might help the biological interpretation of epigenome-wide association studies (EWAS). We aimed to identify autosomal cis eQTMs in children's blood, using data from 832 children of the Human Early Life Exposome (HELIX) project.<h4>Methods</h4>Blood DNA methylation and gene expression were measured with the Illumina 450K and the Af ...[more]
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