Elucidating the structural-functional connectome of language in glioma-induced aphasia using nTMS and DTI.

ABSTRACT: Glioma-induced aphasia (GIA) is frequently observed in patients with newly diagnosed gliomas. Previous studies showed an impact of gliomas not only on local brain regions but also on the functionality and structure of brain networks. The current study used navigated transcranial magnetic stimulation (nTMS) to localize language-related regions and to explore language function at the network level in combination with connectome analysis. Thirty glioma patients without aphasia (NA) and 30 patients with GIA were prospectively enrolled. Tumors were located in the vicinity of arcuate fasciculus-related cortical and subcortical regions. The visualized ratio (VR) of each tract was calculated based on their respective fractional anisotropy (FA) and maximal FA. Using a thresholding method of each tr

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8933329 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature