Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC8933458 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Li Gaocai G Ma Liang L He Shujie S Luo Rongjin R Wang Bingjin B Zhang Weifeng W Song Yu Y Liao Zhiwei Z Ke Wencan W Xiang Qian Q Feng Xiaobo X Wu Xinghuo X Zhang Yukun Y Wang Kun K Yang Cao C
Nature communications 20220318 1
N6-methyladenosine (m<sup>6</sup>A) is the most prevalent RNA modification at the posttranscriptional level and involved in various diseases and cellular processes. However, the underlying mechanism of m<sup>6</sup>A regulation in intervertebral disc degeneration (IVDD) remains elusive. Here, we show that methylation of the lncRNA NORAD significantly increases in senescent nucleus pulposus cells (NPCs) by m<sup>6</sup>A sequencing. Subsequent loss- and gain-of-function experiments reveal WTAP is ...[more]