Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents.

ABSTRACT:

Background and aims

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver condition. It is tightly associated with an adverse metabolic phenotype (including obesity and type 2 diabetes) as well as with obstructive sleep apnoea (OSA) of which intermittent hypoxia is a critical component. Hepatic de novo lipogenesis (DNL) is a significant contributor to hepatic lipid content and the pathogenesis of NAFLD and has been proposed as a key pathway to target in the development of pharmacotherapies to treat NAFLD. Our aim is to use experimental models to investigate the impact of hypoxia on hepatic lipid metabolism independent of obesity and metabolic disease.

Methods

Human and rodent studies incorporating stable isotopes and hyperinsulinaemic euglycaemic

SUBMITTER: Hazlehurst JM 

PROVIDER: S-EPMC8933516 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature