A numerical algorithm for modeling cellular rearrangements in tissue morphogenesis.

ABSTRACT: Among morphological phenomena, cellular patterns in developing sensory epithelia have gained attention in recent years. Although physical models for cellular rearrangements are well-established thanks to a large bulk of experimental work, their computational implementation lacks solid mathematical background and involves experimentally unreachable parameters. Here we introduce a level set-based computational framework as a tool to rigorously investigate evolving cellular patterns, and study its mathematical and computational properties. We illustrate that a compelling feature of the method is its ability to correctly handle complex topology changes, including frequent cell intercalations. Combining this accurate numerical scheme with an established mathematical model, we show that the prop

SUBMITTER: Mohammad RZ 

PROVIDER: S-EPMC8933555 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature