Abnormal habenula functional connectivity characterizes treatment-resistant depression.

ABSTRACT:

Background

A significant proportion of patients with major depressive disorder are resistant to antidepressant medication and psychological treatments. A core symptom of treatment-resistant depression (TRD) is anhedonia, or the inability to feel pleasure, which has been attributed to disrupted habenula function - a component of the reward network. This study aimed to map detailed neural circuitry architecture related to the habenula to identify neural mechanisms of TRD.

Methods

35 TRD patients, 35 patients with treatment-sensitive depression (TSD), and 38 healthy controls (HC) underwent resting-state functional magnetic resonance imaging. Functional connectivity analyses were performed using the left and right habenula as seed regions of interest, and the three groups were c

SUBMITTER: Barreiros AR 

PROVIDER: S-EPMC8933564 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature