Pharmacologic interventions for Kawasaki disease in children: A network meta-analysis of 56 randomized controlled trials.

ABSTRACT:

Background

Although the current consensus recommends a standard treatment of high-dose intravenous immunoglobulin with high-dose aspirin to manage Kawasaki disease (KD), the use of different adjunctive therapies remains controversial. The aim of the current network meta-analysis (NMA) was to compare the efficacy and tolerability of different existing interventions for the initial and refractory stages of KD.

Methods

An NMA of randomised controlled trials (RCTs) was conducted using the frequentist model applied after electronic searches in PubMed, Embase, ScienceDirect, ProQuest, ClinicalTrials.gov, ClinicalKey, Cochrane CENTRAL, and Web of Science. The main outcomes were reduced fever duration/diminished severity of fever subsided. The initial stage of KD was defined as the

SUBMITTER: Lei WT 

PROVIDER: S-EPMC8933672 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature