Unknown

Dataset Information

0

Cu-catalyzed, Mn-mediated propargylation and allenylation of aldehydes with propargyl bromides.


ABSTRACT: A simple, practical, and high chemo-selective method for the synthesis of propargyl alcohol and allenyl alcohols via Cu-catalyzed, Mn-mediated propargylation and allenylation of aldehydes with propargyl bromides has been established. When 3-bromo-1-propyne was conducted under the standard condition, the aldehydes were transformed to the corresponding propargylation products completely, while when 1-bromo-2-pentyne was used, allenic alcohol was the only product. Variety of homopropargyl alcohols and allenyl alcohols were obtained in high yields and the reaction is compatible with broad substrate scopes. In addition, the large-scale reaction could also be proceeded smoothly indicating the potential synthetic applications of this transformation.

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8933908 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cu-catalyzed, Mn-mediated propargylation and allenylation of aldehydes with propargyl bromides.

Zhang Rongli R   Xia Yanping Y   Yan Yuchen Y   Ouyang Lu L  

BMC chemistry 20220318 1


A simple, practical, and high chemo-selective method for the synthesis of propargyl alcohol and allenyl alcohols via Cu-catalyzed, Mn-mediated propargylation and allenylation of aldehydes with propargyl bromides has been established. When 3-bromo-1-propyne was conducted under the standard condition, the aldehydes were transformed to the corresponding propargylation products completely, while when 1-bromo-2-pentyne was used, allenic alcohol was the only product. Variety of homopropargyl alcohols  ...[more]

Similar Datasets

| S-EPMC10415309 | biostudies-literature
| S-EPMC5718194 | biostudies-literature
| S-EPMC3334334 | biostudies-literature
| S-EPMC4965293 | biostudies-literature
| S-EPMC11423103 | biostudies-literature
| S-EPMC8392099 | biostudies-literature
| S-EPMC6368192 | biostudies-literature
| S-EPMC8279488 | biostudies-literature
| S-EPMC7579671 | biostudies-literature
| S-EPMC2976063 | biostudies-literature