New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study.

ABSTRACT:

Background

Traumatic brain injury (TBI) has been reported as a risk factor for brain cancer development. However, the magnitude of the impact of TBI on systemic cancer development has not been clarified.

Methods

A retrospective longitudinal cohort study was conducted using the Taiwan Longitudinal Health Insurance Database between January 2000 and December 2011. A total of 35,306 patients were initially enrolled, and 14,795 patients with mild TBI and 14,795 patients with moderate/severe TBI were matched using the National Health Insurance Research Database in Taiwan. The Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of TBI adjusted for potential confounding factors.

Results

After matching, the results showed that patients with mode

SUBMITTER: Lu CC 

PROVIDER: S-EPMC8933911 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature