Identifying genes with conserved splicing structure and orthologous isoforms in human, mouse and dog.

ABSTRACT:

Background

In eukaryote transcriptomes, a significant amount of transcript diversity comes from genes' capacity to generate different transcripts through alternative splicing. Identifying orthologous alternative transcripts across multiple species is of particular interest for genome annotators. However, there is no formal definition of transcript orthology based on the splicing structure conservation. Likewise there is no public dataset benchmark providing groups of orthologous transcripts sharing a conserved splicing structure.

Results

We introduced a formal definition of splicing structure orthology and we predicted transcript orthologs in human, mouse and dog. Applying a selective strategy, we analyzed 2,167 genes and their 18,109 known transcripts and identified a set o

SUBMITTER: Guillaudeux N 

PROVIDER: S-EPMC8933948 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature