Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study.

ABSTRACT:

Background

Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population.

Methods

The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique.

Results

The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P_corr > 0.05). However, carriers of II genotype were less frequent in the RAS group

SUBMITTER: Bartakova J 

PROVIDER: S-EPMC8933959 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature