Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 vaccines in Hong Kong.

ABSTRACT:

Background and objective

Few head-to-head evaluations of immune responses to different vaccines have been reported.

Methods

Surrogate virus neutralization test (sVNT) antibody levels of adults receiving either two doses of BNT162b2 (n = 366) or CoronaVac (n = 360) vaccines in Hong Kong were determined. An age-matched subgroup (BNT162b2 [n = 49] vs. CoronaVac [n = 49]) was tested for plaque reduction neutralization (PRNT) and spike-binding antibody and T-cell reactivity in peripheral blood mononuclear cells.

Results

One month after the second dose of vaccine, BNT162b2 elicited significantly higher PRNT₅₀ , PRNT₉₀ , sVNT, spike receptor binding, spike N-terminal domain binding, spike S2 domain binding, spike FcR binding and antibody avidity levels

SUBMITTER: Mok CKP 

PROVIDER: S-EPMC8934254 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature