Dataset Information
Mechanism of Action of Mesenchymal Stem Cells (MSCs): impact of delivery method.
Ontology highlight
ABSTRACT: Introduction
Mesenchymal stromal cells (MSCs; AKA mesenchymal stem cells) stimulate healing and reduce inflammation. Promising therapeutic responses are seen in many late-phase clinical trials, but others have not satisfied their primary endpoints, making translation of MSCs into clinical practice difficult. These inconsistencies may be related to the route of MSC delivery, lack of product optimization, or varying background therapies received in clinical trials over time.Areas covered
Here we discuss the different routes of MSC delivery, highlighting the proposed mechanism(s) of therapeutic action as well as potential safety concerns. PubMed search criteria used: MSC plus: local administration; routes of administration; delivery methods; mechanism of action; therapy in different diseases.Expert opinion
Direct injection of MSCs using a controlled local delivery approach appears to have benefits in certain disease states, but further studies are required to make definitive conclusions regarding the superiority of one delivery method over another.
SUBMITTER: Bagno LL
PROVIDER: S-EPMC8934282 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Mechanism of Action of Mesenchymal Stem Cells (MSCs): impact of delivery method.
Expert opinion on biological therapy 20211227 4
<h4>Introduction</h4>Mesenchymal stromal cells (MSCs; AKA mesenchymal stem cells) stimulate healing and reduce inflammation. Promising therapeutic responses are seen in many late-phase clinical trials, but others have not satisfied their primary endpoints, making translation of MSCs into clinical practice difficult. These inconsistencies may be related to the route of MSC delivery, lack of product optimization, or varying background therapies received in clinical trials over time.<h4>Areas cover ...[more]
