Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.

ABSTRACT:

Background & aims

Owing to the lack of genetic animal models that adequately recreate key clinical characteristics of cirrhosis, the molecular pathogenesis of cirrhosis has been poorly characterized, and treatments remain limited. Hence, we aimed to better elucidate the pathological mechanisms of cirrhosis using a novel murine model.

Methods

We report on the first murine genetic model mimicking human cirrhosis induced by hepatocyte-specific elimination of microspherule protein 1 (MCRS1), a member of non-specific lethal (NSL) and INO80 chromatin-modifier complexes. Using this genetic tool with other mouse models, cell culture and human samples, combined with quantitative proteomics, single nuclei/cell RNA sequencing and chromatin immunoprecipitation assays, we investigated me

SUBMITTER: Garrido A 

PROVIDER: S-EPMC8934297 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature