Design and Synthesis of Dipeptidomimetic Isocyanonaphthalene as Enhanced-Fluorescent Chemodosimeter for Sensing Mercury Ion and Living Cells.

ABSTRACT: A novel valine-based isocyanonaphthalene (NpI) was designed and synthesized by using an easy method and enabled the selective fluorescence detection of Hg²⁺. The chemodosimeter can display an immediate turn-on fluorescence response (500-fold) towards target metal ions upon the Hg²⁺-mediated conversion of isocyano to amino within NpI. Based on this specific reaction, the fluorescence-enhancement probe revealed a high sensitivity toward Hg²⁺ over other common metal ions and exhibited excellent aqueous solubility, good antijamming capability, high sensitivity (detection limit: 14.2 nM), and real-time detection. The response mechanism of NpI was supported by NMR spectroscopy, MS analysis and DFT theoretical calculation using various techniq

SUBMITTER: Wang XJ 

PROVIDER: S-EPMC8934403 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature