Causal Relationships Between Osteoarthritis and Senile Central Nerve System Dysfunction: A Bidirectional Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

The relationship between osteoarthritis (OA) and senile central nervous system dysfunctions (CNSDs), including Parkinson's disease (PD), Alzheimer's disease (AD), and ischemic stroke (IS) has gradually attracted attention. At present, the causal relationship between OA and CNSD remains unclear. The aim of this study was to assess the causal effects of CNSD and OA using Mendelian randomization (MR).

Methods

Genome-wide association study summary data for CNSD and OA were obtained. Single-nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs), and significant (P < 5.0 × 10^-8) and independent (r ² < 0.1) SNPs were extracted for bidirectional MR analysis. Inverse variance weighted (IVW) was used to assess these

SUBMITTER: Cai Y 

PROVIDER: S-EPMC8934417 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature