FGF4, A New Potential Regulator in Gestational Diabetes Mellitus.

ABSTRACT: Background: Gestational diabetes mellitus (GDM) is associated with adverse maternal and neonatal outcomes, however the underlying mechanisms remain elusive. The aim of this study was to find efficient regulator of FGFs in response to the pathogenesis of GDM and explore the role of the FGFs in GDM. Methods: We performed a systematic screening of placental FGFs in GDM patients and further in two different GDM mouse models to investigate their expression changes. Significant changed FGF4 was selected, engineered, purified, and used to treat GDM mice in order to examine whether it can regulate the adverse metabolic phenotypes of the diabetic mice and protect their fetus. Results: We found FGF4 expression was elevated in GDM patients and its level was positively correlated

SUBMITTER: Fan M 

PROVIDER: S-EPMC8934430 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature