Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90⁺ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is a highly prevalent human degenerative joint disorder that has long plagued patients. Glucocorticoid injection into the intra-articular (IA) cavity provides potential short-term analgesia and anti-inflammatory effects, but long-term IA injections cause loss of cartilage. Synovial mesenchymal stem cells (MSCs) reportedly promote cartilage proliferation and increase cartilage content.

Methods

CD90⁺ MCS-derived micro-vesicle (CD90@MV)-coated nanoparticle (CD90@NP) was developed. CD90⁺ MCSs were extracted from human synovial tissue. Cytochalasin B (CB) relaxed the interaction between the cytoskeleton and the cell membranes of the CD90⁺ MCSs, stimulating CD90@MV secretion. Poly (lactic-co-glycolic acid) (PLGA) nano

SUBMITTER: Li Y 

PROVIDER: S-EPMC8934450 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature