MRNA expression analysis of the hippocampus in a vervet monkey model of fetal alcohol spectrum disorder.

ABSTRACT:

Background

Fetal alcohol spectrum disorders (FASD) are common, yet preventable developmental disorders that stem from prenatal exposure to alcohol. This exposure leads to a wide array of behavioural and physical problems with a complex and poorly defined biological basis. Molecular investigations to date predominantly use rodent animal models, but because of genetic, developmental and social behavioral similarity, primate models are more relevant. We previously reported reduced cortical and hippocampal neuron levels in an Old World monkey (Chlorocebus sabaeus) model with ethanol exposure targeted to the period of rapid synaptogenesis and report here an initial molecular study of this model. The goal of this study was to evaluate mRNA expression of the hippocampus at two different b

SUBMITTER: Gillis RF 

PROVIDER: S-EPMC8934503 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature