CTHRC1 is a prognosis-related biomarker correlated with immune infiltrates in colon adenocarcinoma.

ABSTRACT:

Background

Colon adenocarcinoma (COAD) is one of the common cancers worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been reported to be involved in cell invasion, angiogenesis, and the promotion of epithelial-mesenchymal transformation by mediating multiple signaling pathways. However, the role of CTHRC1 in COAD has not yet been determined.

Methods

Differentially expressed genes were evaluated using gene expression data from the Oncomine and TIMER databases. Correlations between CTHRC1 gene expression and clinicopathological factors were analyzed using gene expression data from UALCAN databases. Then, we searched the GEPIA database to evaluate the association of CTHRC1 gene expression with clinical outcomes. The cBioPortal database was used to analyze CTHRC

SUBMITTER: Meng C 

PROVIDER: S-EPMC8934523 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature