Mechanisms and physiological implications of cooperative gating of clustered ion channels.

ABSTRACT: Ion channels play a central role in the regulation of nearly every cellular process. Dating back to the classic 1952 Hodgkin-Huxley model of the generation of the action potential, ion channels have always been thought of as independent agents. A myriad of recent experimental findings exploiting advances in electrophysiology, structural biology, and imaging techniques, however, have posed a serious challenge to this long-held axiom, as several classes of ion channels appear to open and close in a coordinated, cooperative manner. Ion channel cooperativity ranges from variable-sized oligomeric cooperative gating in voltage-gated, dihydropyridine-sensitive Ca_V1.2 and Ca_V1.3 channels to obligatory dimeric assembly and gating of voltage-gated Na_V1.5 channels. Po

SUBMITTER: Dixon RE 

PROVIDER: S-EPMC8934683 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature