Analysis of Gene Expression Profiles in the Liver of Rats With Intrauterine Growth Retardation.

ABSTRACT:

Background

Intrauterine growth restriction (IUGR) is highly associated with fetal as well as neonatal morbidity, mortality, and an increased risk metabolic disease development later in life. The mechanism involved in the increased risk has not been established. We compared differentially expressed genes between the liver of appropriate for gestational age (AGA) and IUGR rat models and identified their effects on molecular pathways involved in the metabolic syndrome.

Methods

We extracted RNA from the liver of IUGR and AGA rats and profiled gene expression by microarray analysis. GO function and KEGG pathway enrichment analyses were conducted using the Search Tool for the Retrieval of Interacting Genes database. Then, the Cytoscape software was used to visualize regulatory int

SUBMITTER: Shen Z 

PROVIDER: S-EPMC8934861 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature