Eyes on amyloidosis: microvascular retinal dysfunction in cardiac amyloidosis.

ABSTRACT:

Aims

Cardiac involvement in systemic amyloidosis is a marker of particularly poor prognosis. Cardiac amyloidosis (CA) is characterized by extracellular amyloid deposits inducing heart failure and symptoms of cardiac microvascular disease. While amyloid deposition is most common in the myocardium but also seen in pericardium and endocardium, atria, and vasculature, the role of (micro-)vascular dysfunction in CA pathophysiology remains still elusive. Because vascular function is associated with cardiovascular risk and severity of heart failure and represents a potential therapeutic target in CA, the present study investigated retinal vascular function, flow-mediated dilatation (FMD), and pulse-wave analysis and velocity (PWA/PWV) in patients with CA.

Methods and results

Flicke

SUBMITTER: Zampiccoli E 

PROVIDER: S-EPMC8934987 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature