Lipid levels and the risk of dementia: A dose-response meta-analysis of prospective cohort studies.

ABSTRACT:

Objectives

We performed a dose-response meta-analysis to estimate the association between lipid profiles with the risk of dementia and the potential differences according to the subtype of dementia based on prospective studies.

Methods

We searched PubMed, Embase and Web of Science for relevant articles and performed a meta-analysis. We applied fixed or random-effects models to calculate pooled relative risk (RR) with their 95% confidence intervals (CI). The dose-response relationship was assessed by restricted cubic spline.

Results

Twenty-five prospective studies comprising 362,443 participants and 20,121 cases were included in the final analysis. We found that increased risk of all-cause dementia could be predicted by elevated total cholesterol (TC) (RR = 1.13, 95% C

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC8935316 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature