A phytic acid analogue INS-3001 prevents ectopic calcification in an Abcc6^-/- mouse model of pseudoxanthoma elasticum.

ABSTRACT: Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic calcification disorders, affects the skin, eyes and the cardiovascular system due to inactivating mutations in the ABCC6 gene. There is no effective treatment for the systemic manifestations of PXE. In this study, the efficacy of INS-3001, an analogue of phytic acid, was tested for inhibition of ectopic calcification in an Abcc6^-/- mouse model of PXE. In prevention study, Abcc6^-/- mice, at 6 weeks of age, the time of onset of ectopic calcification, were treated with INS-3001 with 0.16, 0.8, 4, 20 or 100 mg/kg/day administered by subcutaneous implantation of osmotic pumps, as well as 4 mg/kg/day by subcutaneous injection thrice weekly or 14, 4 and 0.8 mg/kg/day once weekly subcutaneous injection. Mice wer

SUBMITTER: Jacobs IJ 

PROVIDER: S-EPMC8935358 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature