Intravitreal administration of recombinant human opticin protects against hyperoxia-induced pre-retinal neovascularization.

ABSTRACT: Opticin is an extracellular glycoprotein present in the vitreous. Its antiangiogenic properties offer the potential for therapeutic intervention in conditions such as proliferative diabetic retinopathy and retinopathy of prematurity. Here, we investigated the hypothesis that intravitreal administration of recombinant human opticin can safely protect against the development of pathological angiogenesis and promote its regression. We generated and purified recombinant human opticin and investigated its impact on the development and regression of pathological retinal neovascularization following intravitreal administration in murine oxygen-induced retinopathy. We also investigated its effect on normal retinal vascular development and function, following intravitreal injection in neonatal mice

SUBMITTER: Klaska IP 

PROVIDER: S-EPMC8935380 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature