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Long-chain omega-3 polyunsaturated fatty acids and the risk of heart failure.


ABSTRACT:

Aims

Adequate intake of long-chain (LC) omega-3 polyunsaturated fatty acids (n-3 PUFAs) is considered important for cardiovascular health. However, the effects of LC n-3 PUFAs on the risk of heart failure (HF) remain unclear. This systematic review and meta-analysis aimed to determine the role of LC n-3 PUFAs in the incidence of HF.

Materials and methods

Electronic databases were searched for studies up to 31 July 2021. Studies were included for the meta-analysis if they reported the adjusted associations between different dietary intakes or circulating concentrations of LC n-3 PUFAs and the risk of HF. A random-effect model was used to calculate the pooled estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for higher LC n-3 PUFA concentrations.

Results

Thirteen studies were included in the meta-analysis. Eight studies comprising 316,698 individuals (11,244 incident HF cases), with a median follow-up of 10.7 years, showed that a higher dietary intake of LC n-3 PUFAs was associated with a lower risk of HF (highest versus lowest quintile: HR = 0.84, 95% CI = 0.75-0.94). Six studies, comprising 17,163 participants (2520 HF cases) with a median follow-up of 9.7 years, showed that higher circulating LC n-3 PUFA concentrations were associated with a lower risk of HF (highest versus lowest quintile: HR = 0.59, 95% CI = 0.39-0.91). Higher circulating docosahexaenoic acid concentrations were associated with a decreased risk of HF (top versus bottom quintile: HR = 0.44, 95% CI = 0.26-0.77). The associations between eicosapentaenoic acid (HR = 0.58, 95% CI = 0.26-1.25), docosahexaenoic acid (HR = 0.66, 95% CI = 0.24-1.82), and the risk of HF were not significant.

Conclusion

High LC n-3 PUFA concentrations measured by dietary intake or circulating biomarkers are associated with a lower risk of developing HF.

SUBMITTER: Zheng S 

PROVIDER: S-EPMC8935400 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Long-chain omega-3 polyunsaturated fatty acids and the risk of heart failure.

Zheng Sulin S   Qiu Min M   Wu Jason H Y JHY   Pan Xiong-Fei XF   Liu Xiong X   Sun Lichang L   Zhu Hailan H   Wu Jiandi J   Huang Yuli Y  

Therapeutic advances in chronic disease 20220318


<h4>Aims</h4>Adequate intake of long-chain (LC) omega-3 polyunsaturated fatty acids (<i>n</i>-3 PUFAs) is considered important for cardiovascular health. However, the effects of LC <i>n</i>-3 PUFAs on the risk of heart failure (HF) remain unclear. This systematic review and meta-analysis aimed to determine the role of LC <i>n</i>-3 PUFAs in the incidence of HF.<h4>Materials and methods</h4>Electronic databases were searched for studies up to 31 July 2021. Studies were included for the meta-analy  ...[more]

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