Alkalising agents in urinary tract infections: theoretical contraindications, interactions and synergy.

ABSTRACT:

Introduction

Alkalising agents have the potential to enhance the efficacy of many antimicrobial agents used in the treatment of Urinary Tract Infections; they also have the potential to cause significant patient harm if used incorrectly. This work seeks to illustrate and quantify these risks and synergies by modelling drug solubility and supersaturation against pharmacokinetic data for commonly used antibiotic agents.

Methods

Solubility-pH relationships are employed to quantify the crystalluria risk for compounds which may be reasonably expected to be co-prescribed-or co-administered-with urinary alkalisers (amoxicillin, nitrofurantoin, trimethoprim, sulfamethoxazole and ciprofloxacin). These results are correlated against reports of crystalluria in the literature and in the

SUBMITTER: Kavanagh ON 

PROVIDER: S-EPMC8935415 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature