Tau deposition and structural connectivity demonstrate differential association patterns with neurocognitive tests.

ABSTRACT: Tau neurofibrillary tangles have a central role in the pathogenesis of Alzheimer's Disease (AD). Mounting evidence indicates that the propagation of tau is assisted by brain connectivity with weakened white-matter integrity along the propagation pathways. Recent advances in tau positron emission tomography tracers and diffusion magnetic resonance imaging allow the visualization of tau pathology and white-matter connectivity of the brain in vivo. The current study aims to investigate how tau deposition and structural connectivity are associated with memory function in prodromal AD. In this study, tau accumulation and structural connectivity data from 83 individuals (57 cognitively normal participants and 26 participants with mild cognitive impairment) were associated with neurocognitive tes

SUBMITTER: Hall Z 

PROVIDER: S-EPMC8935446 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature