Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog.

ABSTRACT: The mammalian dentition is a serially homogeneous structure that exhibits wide numerical and morphological variation among multiple different species. Patterning of the dentition is achieved through complex reiterative molecular signaling interactions that occur throughout the process of odontogenesis. The secreted signaling molecule Sonic hedgehog (Shh) plays a key role in this process, and the Shh coreceptor growth arrest-specific 1 (Gas1) is expressed in odontogenic mesenchyme and epithelium during multiple stages of tooth development. We show that mice engineered with Gas1 loss-of-function mutation have variation in number, morphology, and size of teeth within their molar dentition. Specifically, supernumerary teeth with variable morphology are present mesial to the first molar

SUBMITTER: Seppala M 

PROVIDER: S-EPMC8935464 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature