Iron overload status in patients with non-transfusion-dependent thalassemia in China.

ABSTRACT:

Background

Iron overload is one of the main factors that increase morbidity and mortality in patients with non-transfusion dependent thalassemia (NTDT).

Aim

This study aimed at investigating the prevalence and severity of iron overload in Chinese NTDT patients.

Methods

we analyzed serum ferritin (SF), liver iron concentration (LIC) and cardiac T2* in 178 Chinese NTDT in this cross-sectional study.

Results

The median SF level was 996.00(27.15-19704.00) ng/ml and the median LIC value was 8.90(0.60-43.00) mg Fe/g dry weight (dw). The youngest patient with liver iron overload was 5 years old with 5.6 mg Fe/g dw in LIC. The median cardiac T2* was 33.06(7.46-75.08) ms. 6 patients had cardiac T2*⩽20ms. The patients with β thalassemia intermedia and HbE/β thalassemia s

SUBMITTER: Huang Y 

PROVIDER: S-EPMC8935562 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature