Decreased acylated and total ghrelin levels in bipolar disorder patients recovering from a manic episode.

ABSTRACT:

Background

To date, only few studies have investigated ghrelin levels in bipolar disorders, and all have exclusively measured acylated ghrelin, with none investigating total ghrelin (acylated and des-acylated). We aimed to investigate peripheral levels of acylated and total ghrelin in subjects experiencing a manic episode of bipolar disorder.

Methods

Peripheral levels of acylated and total ghrelin were measured in hospitalised medicated individuals recovering from a manic episode. Enzyme-linked immunosorbent assays (ELISA) were used to measure ghrelin levels in patients and compared with healthy controls. The relationship between ghrelin levels in bipolar disorder, self-reported hunger measures, demographic and clinical parameters was investigated with correlational analyses

SUBMITTER: Abdel Aziz K 

PROVIDER: S-EPMC8935687 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature