Phosphorylation regulation of cardiac proteins in Babesia microti infected mice in an effort to restore heart function.

ABSTRACT:

Background

Babesia is a common protozoan parasite that infects red blood cells. In mice infected with Babesia microti, the red blood cells were lysed, resulting in decreased oxygen-carrying capacity. To compensate for low blood oxygen levels, stress on the heart was greatly increased. Babesiosis induces a variety of pathologies; meanwhile, heart tissues initiate self-repair responses to babesiosis-induced tissue damage to restore heart function.

Methods

To discover the molecular mechanisms of the damage and self-repair in the heart after B. microti infection in mice, we investigated the changes in protein expression and phosphorylation modification levels in heart tissues at 0, 5, 8, 11, and 19 days post-infection using data-independent acquisition (DIA) quantitative proteom

SUBMITTER: Yang X 

PROVIDER: S-EPMC8935697 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature