Identification of differentially expressed genes and signaling pathways with Candida infection by bioinformatics analysis.

ABSTRACT:

Background

Opportunistic Candida species causes severe infections when the human immune system is weakened, leading to high mortality.

Methods

In our study, bioinformatics analysis was used to study the high-throughput sequencing data of samples infected with four kinds of Candida species. And the hub genes were obtained by statistical analysis.

Results

A total of 547, 422, 415 and 405 differentially expressed genes (DEGs) of Candida albicans, Candida glabrata, Candida parapsilosis and Candida tropicalis groups were obtained, respectively. A total of 216 DEGs were obtained after taking intersections of DEGs from the four groups. A protein-protein interaction (PPI) network was established using these 216 genes. The top 10 hub genes (FOSB, EGR1, JUNB, ATF3, EGR2, NR4A1,

SUBMITTER: Zhu GD 

PROVIDER: S-EPMC8935812 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature