Proteomic profiling of hydatid fluid from pulmonary cystic echinococcosis.

ABSTRACT:

Background

Most cystic echinococcosis cases in Southern Brazil are caused by Echinococcus granulosus and Echinococcus ortleppi. Proteomic studies of helminths have increased our knowledge about the molecular survival strategies that are used by parasites. Here, we surveyed the protein content of the hydatid fluid compartment in E. granulosus and E. ortleppi pulmonary bovine cysts to better describe and compare their molecular arsenal at the host-parasite interface.

Methods

Hydatid fluid samples from three isolates of each species were analyzed using mass spectrometry-based proteomics (LC-MS/MS). In silico functional analyses of the identified proteins were performed to examine parasite survival strategies.

Results

The identified hydatid fluid protein profiles showed a

SUBMITTER: Dos Santos GB 

PROVIDER: S-EPMC8935821 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature