Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D₃, Receptor Availability Following Cocaine Self-administration in Rats.

ABSTRACT:

Background

Compulsive patterns of drug use are thought to be the consequence of drug-induced adaptations in the neural mechanisms that enable behavior to be flexible. Neuroimaging studies have found evidence of robust alterations in glutamate and dopamine receptors within brain regions that are known to be critical for decision-making processes in cocaine-dependent individuals, and these changes have been argued to be the consequence of persistent drug use. The causal relationships among drug-induced alterations, cocaine taking, and maladaptive decision-making processes, however, are difficult to establish in humans.

Methods

We assessed decision making in adult male rats using a probabilistic reversal learning task and used positron emission tomography with the [¹¹

SUBMITTER: Groman SM 

PROVIDER: S-EPMC8935943 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature