Epidemiology of Basal-like and Luminal Breast Cancers among Black Women in the AMBER Consortium.

ABSTRACT:

Background

Evidence suggests etiologic heterogeneity among breast cancer subtypes. Previous studies with six-marker IHC classification of intrinsic subtypes included small numbers of black women.

Methods

Using centralized laboratory results for estrogen receptor (ER), progesterone receptor, HER2, proliferation marker, Ki-67, EGFR, and cytokeratin (CK)5/6, we estimated case-only and case-control ORs for established breast cancer risk factors among cases (n = 2,354) and controls (n = 2,932) in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium. ORs were estimated by ER status and intrinsic subtype using adjusted logistic regression.

Results

Case-only analyses by ER status showed etiologic heterogeneity by age at menarche, parity (v

SUBMITTER: Benefield HC 

PROVIDER: S-EPMC8935955 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature