Experimentally imposed circadian misalignment alters the neural response to monetary rewards and response inhibition in healthy adolescents.

ABSTRACT:

Background

Sleep and circadian timing shifts later during adolescence, conflicting with early school start times, and resulting in circadian misalignment. Although circadian misalignment has been linked to depression, substance use, and altered reward function, a paucity of experimental studies precludes the determination of causality. Here we tested, for the first time, whether experimentally-imposed circadian misalignment alters the neural response to monetary reward and/or response inhibition.

Methods

Healthy adolescents (n = 25, ages 13-17) completed two in-lab sleep schedules in counterbalanced order: An 'aligned' condition based on typical summer sleep-wake times (0000-0930) and a 'misaligned' condition mimicking earlier school year sleep-wake times (2000-0530). Partic

SUBMITTER: Hasler BP 

PROVIDER: S-EPMC8935965 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature