The effect of waning on antibody levels and memory B cell recall following SARS-CoV-2 infection or vaccination.

ABSTRACT: As of March 2022, there have been over 450 million reported SARS-CoV-2 cases worldwide, and more than 4 billion people have received their primary series of a COVID-19 vaccine. In order to longitudinally track SARS-CoV-2 antibody levels in people after vaccination or infection, a large-scale COVID-19 sero-surveillance progam entitled SPARTA (SeroPrevalence and Respiratory Tract Assessment) was established early in the pandemic. Anti-RBD antibody levels were tracked in more than 1,000 people. There was no significant decrease in antibody levels during the first 14 months after infection in unvaccinated participants, however, significant waning of antibody levels was observed following vaccination, regardless of previous infection status. Moreover, participants who were pre-immune to SARS-Co

SUBMITTER: Forgacs D 

PROVIDER: S-EPMC8936119 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature