The Association Between Thyroid Diseases and Alzheimer's Disease in a National Health Screening Cohort in Korea.

ABSTRACT:

Objectives

Thyroid dysfunction is linked to an increased risk of cognitive impairment. However, studies on the relationships between thyroid diseases and Alzheimer's disease (AD) have reported conflicting results. We investigated the associations between several thyroid diseases and AD in a nested case-control study.

Methods

A total of 1,977 participants with AD were identified by claims data from 2002-2015 among a random sample of half a million people in the Korean National Health Insurance database. We recruited 16,473 age- and sex-matched (1:4 ratio) control participants and applied conditional logistic regression to estimate the relationships between thyroid diseases and AD, with adjustments for potential confounders, such as basic demographics, lifestyle factors, and v

SUBMITTER: Kim JH 

PROVIDER: S-EPMC8936176 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature