Suppressive Effect of Autocrine FGF21 on Autophagy-Deficient Hepatic Tumorigenesis.

ABSTRACT: Mice with hepatocyte-specific deletion of autophagy-related 7 (Atg7 ^ΔHep mice) develop hepatoma, suggesting that autophagy deficiency could be a factor in the initiation of tumorigenesis. We have shown that FGF21 is induced as a 'mitokine' when Atg7 is disrupted in insulin target tissues such as the liver, which could affect systemic metabolism through endocrine activity. Since FGF21 or other endocrine FGF such as FGF19 can affect tumor growth, we hypothesized that FGF21 produced by Atg7-knockout (KO) hepatocytes may affect the behavior of Atg7-KO hepatoma in an autocrine manner. We, thus, crossed Atg7 ^ΔHep mice with systemic Fgf21-KO (Fgf21 ^-/-) mice to generate Atg7 ^ΔHep Fgf21

SUBMITTER: Kim J 

PROVIDER: S-EPMC8936433 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature