Statistical practice and transparent reporting in the neurosciences: Preclinical motor behavioral experiments.

ABSTRACT: Longitudinal and behavioral preclinical animal studies generate complex data, which may not be well matched to statistical approaches common in this literature. Analyses that do not adequately account for complexity may result in overly optimistic study conclusions, with consequences for reproducibility and translational decision-making. Recent work interrogating methodological shortcomings in animal research has not yet comprehensively investigated statistical shortcomings in the analysis of complex longitudinal and behavioral data. To this end, the current cross-sectional meta-research study rigorously reviewed published mouse or rat controlled experiments for motor rehabilitation in three neurologic conditions to evaluate statistical choices and reporting. Medline via PubMed was queried

SUBMITTER: Hogue O 

PROVIDER: S-EPMC8936466 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature