Tumor cell intrinsic and extrinsic features predict prognosis in estrogen receptor positive breast cancer.

ABSTRACT: Although estrogen-receptor-positive (ER+) breast cancer is generally associated with favorable prognosis, clinical outcome varies substantially among patients. Genomic assays have been developed and applied to predict patient prognosis for personalized treatment. We hypothesize that the recurrence risk of ER+ breast cancer patients is determined by both genomic mutations intrinsic to tumor cells and extrinsic immunological features in the tumor microenvironment. Based on the Cancer Genome Atlas (TCGA) breast cancer data, we identified the 72 most common genomic aberrations (including gene mutations and indels) in ER+ breast cancer and defined sample-specific scores that systematically characterized the deregulated pathways intrinsic to tumor cells. To further consider tumor cell extrinsic

SUBMITTER: Yao K 

PROVIDER: S-EPMC8936467 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature