A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease.

ABSTRACT: Neurodegenerative disorders refer to a group of diseases commonly associated with abnormal protein accumulation and aggregation in the central nervous system. However, the exact role of protein aggregation in the pathophysiology of these disorders remains unclear. This gap in knowledge is due to the lack of experimental models that allow for the spatiotemporal control of protein aggregation, and the investigation of early dynamic events associated with inclusion formation. Here, we report on the development of a light-inducible protein aggregation (LIPA) system that enables spatiotemporal control of α-synuclein (α-syn) aggregation into insoluble deposits called Lewy bodies (LBs), the pathological hallmark of Parkinson disease (PD) and other proteinopathies. We demonstrate that LIPA-α-syn i

SUBMITTER: Berard M 

PROVIDER: S-EPMC8936469 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature