Common exacerbation-prone phenotypes across asthma and chronic obstructive pulmonary disease (COPD).

ABSTRACT:

Background and objectives

Chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease (COPD), are complex syndromes with diverse clinical symptoms due to multiple pathophysiological conditions. In this study, using common and shared risk factors for the exacerbation of asthma and COPD, we sought to clarify the exacerbation-prone phenotypes beyond disease labels, and to specifically investigate the role of the IL4RA gene polymorphism, which is related to type 2 inflammation, in these exacerbation-prone phenotypes.

Methods

The study population comprised patients with asthma (n = 117), asthma-COPD overlap (ACO; n = 37) or COPD (n = 48) and a history of exacerbation within the previous year. Cluster analyses were performed using factors assoc

SUBMITTER: Hyodo K 

PROVIDER: S-EPMC8936473 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature