Pruritus: A Sensory Symptom Generated in Cutaneous Immuno-Neuronal Crosstalk.

ABSTRACT: Pruritus or itch generated in the skin is one of the most widespread symptoms associated with various dermatological and systemic (immunological) conditions. Although many details about the molecular mechanisms of the development of both acute and chronic itch were uncovered in the last 2 decades, our understanding is still incomplete and the clinical management of pruritic conditions is one of the biggest challenges in daily dermatological practice. Recent research revealed molecular interactions between pruriceptive sensory neurons and surrounding cutaneous cell types including keratinocytes, as well as resident and transient cells of innate and adaptive immunity. Especially in inflammatory conditions, these cutaneous cells can produce various mediators, which can contribute to the excit

SUBMITTER: Szollosi AG 

PROVIDER: S-EPMC8937025 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature