Contextual control of conditioned pain tolerance and endogenous analgesic systems.

ABSTRACT: The mechanisms underlying the transition from acute to chronic pain are unclear but may involve the persistence or strengthening of pain memories acquired in part through associative learning. Contextual cues, which comprise the environment in which events occur, were recently described as a critical regulator of pain memory; both male rodents and humans exhibit increased pain sensitivity in environments recently associated with a single painful experience. It is unknown, however, how repeated exposure to an acute painful unconditioned stimulus in a distinct context modifies pain sensitivity or the expectation of pain in that environment. To answer this question, we conditioned mice to associate distinct contexts with either repeated administration of a mild visceral pain stimulus (intrape

SUBMITTER: Trask S 

PROVIDER: S-EPMC8937231 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature